Significance of photobiomodulation therapy in increasing stability of orthodontic mini-implants: a systematic review and meta-analysis

1Kotryna Jasinskaitė, Abdulla Varoneckas, Urtė Mackevičiūtė

1Lithuanian University of Health Sciences


Background and aim. Although OMIs made a huge progress in orthodontic treatment, occasional failures such as looseness of OMIs during treatment have not been avoided. Lately studies on photobiomodulation therapy (PBMT) showed its positive impact on stability of OMIs. The aim of this systematic review and meta-analysis was to estimate the impact of PBMT on the stability of OMIs.

Materials and methods. Electronic data base search was carried out according to PRISMA principles. PubMed, Research Gate, The Cochrane Library and Wiley Online Library were used to browse the literature. Statistical analysis was conducted with the Review Manager 5.4.1. A meta-analysis was performed by using Standartized mean difference and random effect. Heterogeneity of the studies was assessed using Cochran’s Q and I2 tests.

Results. After full-text analysis, 7 articles were included. All 7 studies were pooled into meta-analysis and quantitative synthesis was performed. Meta-analysis revealed that PBMT statistically increases OMI stability 1 and 2 months after OMIs were placed. No significant heterogeneity was found between respective studies.

Conclusion. Based on present meta-analysis, LLLT irradiation on OMIs increases their secondary stability and, therefore, could be implemented clinically as adjunctive therapy to promote secondary OMI stability. However, future randomly controlled studies with larger study groups are needed to further confirm the study results.

Keywords: “Laser therapy”, “Orthodontic anchorage”, “Mini-implants”.