Austėja Šakaityė¹, Tadas Raudonis²

¹Vilnius University, Faculty of Medicine, Vilnius, Lithuania

²Vilnius University, Centre of Dermatovenereology, Vilnius, Lithuania

Abstract

Introduction. Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder characterised by painful lesions found in areas with apocrine glands. HS is estimated to affect approximately 1% of the general population, with a higher incidence in females. Treatment remains challenging due to limited understanding of its causes, but recent research has paved the way for new therapeutic options.

Aim. Summarize and present information on HS local, systemic, and surgical treatment based on the latest scientific literature.

Methods. The literature review was performed using PubMed, The Wiley Online Library, and ScienceDirect databases. The following keywords and combinations of them were used: hidradenitis suppurativa, anti-bacterial agents, biological therapy, surgical therapy. Only articles written in English were selected.

Results. For mild and localised cases of HS with few lesions, topical clindamycin 1% may be considered. Patients with Hurley stages II/III and multiple ongoing lesions are often treated with systemic clindamycin combined with rifampicin 300 mg twice daily for about 10 weeks. Adalimumab is the preferred option for moderate to severe HS cases when traditional treatments fail, with clinical response rates ranging from 41.8% to 58.9%. Surgical interventions range from minimally invasive techniques like laser treatments, incision and drainage, deroofing, to more extensive procedures like wide local excisions.

Conclusions. Treatment for HS varies based on severity, ranging from local treatments for mild cases to systemic interventions like antibiotics and biological therapy for severe cases. Surgical options are also available. Managing concurrent conditions, weight, and quitting smoking are vital for better outcomes.

Keywords: hidradenitis suppurativa, anti-bacterial agents, biological therapy, surgical therapy.

Full article

https://doi.org/10.53453/ms.2024.5.7

Local, systemic and surgical treatment of hidradenitis

suppurativa - literature review

Austėja Šakaityė

1

, Tadas Raudonis

2

1

Vilnius University, Faculty of Medicine, Vilnius, Lithuania

2

Vilnius University, Centre of Dermatovenereology, Vilnius, Lithuania

Abstract

Introduction

                      

 !

 

Aim"  



Methods !#$ !%&' (

!) *

  &+

Results, 

#--.---

/0001

 23

4356 

  

Conclusions !                        

                          

$  6

Keywords) *  

Journal of Medical Sciences. 5 May, 2024 - Volume 12 | Issue 3. Electronic - ISSN: 2345-0592

Medical Sciences 2024 Vol. 12 (3), p. 57-62, https://doi.org/10.53453/ms.2024.5.7

57

1. Introduction

          



            

 

             



 

 !

          

 

          

 

      7  !      



1 6

        6     7

!

          

        8

              

          

/

2. Methods

!          

#$  !  %  &  '  

( ! 

)

  *    

   &  

+      !  9    



0

3. Results

3.1. Local and Systemic Treatment

!

          !

            



 2:*

            ;1  

    (  '  <  -

('<-          

     

2=>

:      "  

 "



 *

            

 ?=5!

6



4-

        

 0@*

 60

 

        



-

-.--*

        

A

    #    

6

          

   7  1      



7 >#

--.--- 

          

        

  /00A      

          

  0   /  1    

+          

-

Journal of Medical Sciences. 5 May, 2024 - Volume 12 | Issue 3. Electronic - ISSN: 2345-0592

58

            

            

          

 ?            

0.

 200 

"  400          



---$"

 

          7   2  ,

              

        *    

 

     

    "    



            

2 4-

            

 

   >  !  #  /    

          *

*          

            :

          7  !  



          

-#-&8++B- 

23A7>0A #-&8++B--

43A57?>A?

#!*

?!

              

-'*?1

    *-'*?1      

3 5!/ 

          !  

       

        :

B:B 40A



              

            

 >*-@8-8+

 

          

 :B> 

24A  

        /2A  -    @8B-+  

:B

    27A        



    2>A          

          

              

/A70

+    

              

            

*    !      

            

          

        

    (          

              

!

            *

      *

    

 

*    

(

7 77

- 



              

-

            

  !          

Journal of Medical Sciences. 5 May, 2024 - Volume 12 | Issue 3. Electronic - ISSN: 2345-0592

59

            

           

7/

!

!

              



          

72

3.2. Surgery

;        

6

!

          

                

            

    C      

          

* 

  *6        



            

74

-              

              

        

8  C          



             /

          

 *!*+

+ # !++#  

!

            

              

 7>+

         /

:            *

            

              

 7? 73  1    



  @            

            

8

            

        9    

75

3.3. Prognosis

!              

                

                





&77**

 /52

-

            

              

 

6

- 

          

6*8

 

   

            

/0

4. Conclusions

!

 6

-

            

          

1

          

!

Journal of Medical Sciences. 5 May, 2024 - Volume 12 | Issue 3. Electronic - ISSN: 2345-0592

60



 



References

 D: (8 +' 

B    -  (  EF"  -      +  

          

.E+

1    (    ;

704G752)>5=22

7 H  %  D  ::  #  +  E

HI+ !"! +*     

.

+

  B  +  $  (  70>

G?/)/2/=4

/ H  B    I+  #  $E

  )  :    

 E   11 

(7070$G374)0>=37

2 -  EB  :  ,  I  (  I  !

I E  :  $,      I 1  

(   

703IE

(705$G304)005=?

4 11  : 11 1B

I 1  I  :      8 1

        

)1@

  :    

,)#-)(  



E11(705EG3)?>=50

> D  ::  I  ,H  (*I

E'  H  %  F  I    B    

  .  )    

"*

          

1''-18:+E+1(

;705EG//)5=/

? D:: (8 +' 

B+  -  (  EF"  -      +  

          

.    E  +  1  (

;7041G752)>5=22

3 ' #  $    8  I  J  E !

          

E1

1(705$G30/)37=7

5 ($E J1I#"

        

  E  1  1  (  704

8G?/4)?4

0 B  #!  I  E  #  +#    ($'

(  -+  +  '      -



)1    E 1 1( 70>

(G?4>)4=4

 %  (  %   1  B  '*

        

    E  1  1  (

70>8G?44)045=>7

7 EHI %#!

            

    E  1  1  (

553(G/5>)5?=2

/     JB  KI    #

+#  :          

IE(7070

(G3/>)?3=3?

2 E*'  &  :    E  E#  H*

B #L , +

**"  

      (

70,G777)25=43

4 E*'& :*I EE#

(  $  H*B    #L      

+          

)                /0

Journal of Medical Sciences. 5 May, 2024 - Volume 12 | Issue 3. Electronic - ISSN: 2345-0592

61

    E  1  :

70>,G?7)4/=70

> B: MM $E! -EB ,

E%  !  E      !        

)

  "  N  I  E  

(7077&G3?2)47/=/0

? J  1I  &  $$  %  (1

H1I #J1 D:: !

#  /  !    1    

  8  +  E  $  70>  1

2G/?44)277=/2

3 $I :$ B $1

J !1$ 

-:"(!?)!

:  1  %  -  :    1*!8,

!  E    -  (

70?G/?)7/35=54

5 $O ""PE I1 8*

"( "E:-

-'*?   

)-*

-'*?E11

(70?G?>2)>?0=4

70 J1I EHI+ 11 BD

H1I  I ,H 

**    

@8-8+@8B-+)>

47          

  *  *

  /    '  707/  $

2G200/?3)?2?=>

7   8  !    

*

      

   

(&E70/84G5)70>>

77 ,"E$ !1$ I$

&  '1;    E'    ;M  #

      

)E(!

7077$G///)?27=4

7/ IQ$D $RE IQ1 $Q

I  @    B  I

        1

(:7070EG73)5=/

72 1  :  1  1  1  1  !

          

 : $

70?EG/>7)43=>

74 B J# #1 ,J

&*'"  1H  !"  !      

!E:$

707717G5)7/

7> D #+# IE()

*6

          

E11(700G>//)2?4=

30

7? E  HI    @    

    E  1  1  (

55>EG/2>)552=5

73   (+$  #  I%  $  #

  )    

IE#700/EG4>4)24=

>

75 ;J $ $8 

  I  !  1  B  '

&        )

-          9

    -  E  (  703

EG4?)>7=5

/0 J:I (-+ + IE

#+# EHI+B 

  K      

)KIE

(702&G?2)35=72

Journal of Medical Sciences. 5 May, 2024 - Volume 12 | Issue 3. Electronic - ISSN: 2345-0592

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