Akvilė Gečaitė1
1Vilnius University, Faculty of Medicine, Vilnius, Lithuania
Abstract
Background. Hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality. Treatment resistant hypertension is identified in about 20 % of hypertensive cases, with few treatment options. Recently, modification of intestinal microbiome to the treatment of arterial hypertension has met increasing scientific interest.
Aim: to review the association between intestinal microbial dysbiosis and hypertension as a potential therapeutic approach.
Methods. The literature review was performed based on the scientific database of PubMed. Systematic reviews and meta-analyzes no older than 10 years were included. A total of 21 articles were reviewed, of which 6 were rejected.
Results. Intestinal dysbiosis can lead to the development of arterial hypertension. Lower intestinal microbiome diversity and specific intestinal bacteria have been found to be associated with arterial hypertension. The intestinal microbiome is modifiable by multiple mechanisms, including probiotics, fecal microbial transplant, and the use of trimethylamine N-oxide lyase inhibitor.
Conclusions. Modulation of the intestinal microbiota can be considered as a potential treatment method for arterial hypertension.
Keywords: arterial hypertension, intestinal microbiota, dysbiosis