Ieva Kunickaitė¹

¹Vilnius University, Faculty of Medicine, Vilnius, Lithuania

Abstract

Introduction. Dry eye syndrome (DES) is a tear film disorder caused by decreased tear production or instability of the tear film. Prevalence of DES ranges from 5% to 87.5% worldwide. The most common recommendation for the treatment of DES is the use of preservative-free artificial tears, but the latest data suggest the use of autologous blood serum eye drops.

Aim. Summarize and present information on DES treatment using autologous blood serum eye drops based on the latest scientific literature.

Methods. The literature review was performed using PubMed and ScienceDirect databases. Scientific articles were analyzed by keywords and their combinations: dry eye syndrome, treatment, autologous serum, artificial tears. Exclution criteria were applied to articles related to keratoconjunctivitis sicca. 21 publications were examined. Only articles written in English were selected.

Results. The efficacy of autologous serum (AS) eye drops as treatment of DES is reported in the literature: in 30-100% of cases the symptoms were relieved and in 39-61% of the cases the corneal staining with fluorescein became less pronounced. The results of another study revealed that tear film decay time and visual acuity were significantly increased using AS eye drops 4 times daily for 8 weeks.

Conclusions. Autologous blood serum eye drops used to treat severe DES are effective in reducing conjunctivitis and corneal inflammation. However, the increase in tear release is not affected by this treatment.

Keywords: dry eye syndrome, treatment, autologous serum, artificial tears.

Full article

https://doi.org/10.53453/ms.2023.1.2

Dry eye syndrome treatment with autologous blood serum eye

drops: literature review

Ieva Kunickaitė

1

1

Vilnius University, Faculty of Medicine, Vilnius, Lithuania

Abstract

Introduction.DES

 !!"

#$



Aim.%



Methods."!!&

!%'!($$$

 )! '* +,  !

)-!!

Results. "AS(

./#,//!.0#1,!

"!

23!'

Conclusions. 2                          

*4!$

Keywords: $$$

Journal of Medical Sciences. 23 Jan, 2023 - Volume 11 | Issue 1. Electronic - ISSN: 2345-0592

Medical Sciences 2023 Vol. 11 (1), p. 10-15, https://doi.org/10.53453/ms.2023.1.2

10

Sausų akių sindromo gydymo autologiniu kraujo serumu išeitys:

literatūros apžvalga

Ieva Kunickaitė

1

1

Vilniaus universitetas, Medicinos fakultetas, Vilnius, Lietuva

Santrauka

Įvadas. 5  '5   SAS    65  77  '$   7  87*  65

6577 92*' $

8  2    '*  #  5  65    '5  *$  :  *

;'*'56

Tikslas. <*;$  2 '*

6

Metodai. =;  8   ' * &$   5 % 2%

''88*5'*(5'5$$

$76 2'*'*5'5'

''*'>67+,'*=;6''5'

Rezultatai. =;*'AS'565*''

(./#,//*57*.0?1,*588

6'6@*%'7$**2'563'A65

77'6'67*

Išvados. '   2    *    '*   '5  6   ';

8 *7 8A ":$656'7*6B'



Raktažodžiai: 5'5$$$76

Journal of Medical Sciences. 23 Jan, 2023 - Volume 11 | Issue 1. Electronic - ISSN: 2345-0592

11

1. Įvadas

,.5'5   SAS  65 77

'$    7  87*  65

6577C,D2

    6    5  '5  

8  %5    A  8

2' B7$ '

2*

  '   $  C,D =;*  

2*'(

  65  6$  'B  

''  65  77    '

 ''  65    C,D

82'*#5

65'5*":7

6'*55655

  5  65  '5  CD

=;*'2*;

'*'56

SAS klinika ir sunkumo laipsniai

2  5  E    B  8

$'6'''(

'5$$8$7

';  *  '   8  ;

7*  '$  :    *

   ;  ' F;' 'G  C,D

H'*'

*'5'5'

FOcular Surface Disease Index (OSDI)” 

5  '5  5  'A$  7*

7*A''$:B'A

    C1D  %7  

'*    '   65  77

'  '  A$  &  '5  '*

BA$8AH

  C.D  <  '  

''*  $  2  

'  B  '  B  A$  

''5

2. Metodai

=;  8    '  *

&$5%2%

''88*5

'*(  5  '5  $  $

  $  7  6 2

'* ' *

  5  '5  ' ''*'

>67  +,  '* =;  6'

'5'

3. Rezultatai

SAS gydymas

 =      '   2  *

'*  '  

7  6  DA    '5

28  B    65  77  7B$

'  '  2  "  

'*'5$5

65'*A''56'2

    ''$    ;  '

67*$'6

 6 ' '5'6C,D6

'    ;$  *  

%  ;       (AS

'56C0D

Sunkaus SAS gydymas autologinio kraujo

serumo akių lašais

=;*':2

*  '*    '*

  '5  6  C,D  2  

  *  '*A    6

A26B86

7  7(    *5

'*  4$  6'  

'H'2

%    2$  B'  5  

A  'B 'B 

Journal of Medical Sciences. 23 Jan, 2023 - Volume 11 | Issue 1. Electronic - ISSN: 2345-0592

12

**C DI

  7B  B  $  $

$  '    '    '

C+,D

&$'2*85'5

6'A    '  '  6

%EJCD

":$22'56;'5

=;*$'2'565

;'  86'%$'

;*66*

8  C,3D 8'  5

2  '5  65  'A  6*  '*  C+/D

8A  B'A   '$  7E  6

  A  $  

*$'8656A$

  $  E  B    :

*$8'2'5

65      $  '  *  6

7"6'8

6'5*65*55*$

  *  5$  '    ;  '

65$':5C,0D

SAS gydymo AS akių lašais išeitys

=;*  '  2  '5  65  *

'    '  (  ./#,//

*5    7*    .0?1,  *5

  8      8

6'6C,/#,.D2'5657

6B'.#3'

A$:2'*'7#+/$

3//@*%'7$*

 *2'5 63' 

A      8  

87*1.$6577'7*

1J67*/$/'/$/,

  &2<  ":  H    %

'  'E  C,1D    7*  *'5

55C,/#,.$,1DK

      /J    ,//J

'*      $  '  ,//  

'*    '7  $

  *L  $  :  

'2C, D

4. Išvados

276

85  '5    '5  5  *A

8:5  '    2  

*'*'56

';8*78A

":656'7*6

B'K7$6*;

  ;  '  $  7  ''5

5  6'5  "    ;*

6'    *    '5

'A5

Literatūros šaltiniai

, 2''  @$  2  M$  N  &$  M#

NNO$=2$<&@$K&$&

P$   $&  N   

    Q  -

+/,0O,R,+1,(+1#..3

+ 222$22$222$

2S22$  2  &9$ 2S  2&$

2  2&$  2  &2$  2

24$  2S >T$2  22 

  '              

2&2O

-+/, R+3(1 # .

.   9$  U  $  V  @@$

"2$N'MV$MM$

O$@K$2$= &22

*

>W

+/,/,R,,+(1,+#./

3 O  =$  ! =$ @  $ 9%##

PO&$<$X$"N-

Journal of Medical Sciences. 23 Jan, 2023 - Volume 11 | Issue 1. Electronic - ISSN: 2345-0592

13

U>> &   " <

-+/, OR,.( ?1+

 @*  "$  >  <$    &$  M  $

&Y$@&$"@"



        (   

%  #    2

*      +//  N

,R,.0+(+3+#1

1 9$VOO$V@@<

         )

->>W

+/,,V,R+,+(1./#

 !KO$"P=$O$9

"  <        

"(  "  <    9

  N  &  =  +/,

NR(..

 S%$4O$9%4$9%VMZ

          

  #    P  +//

VR+3(00+? 

0   <$    $  9    2

#      

$

      >4  +/+,

OK0$V,$0&

>

,/ &  Y$    &$  M   et al.

2

    ' Ophthalmology

+//3R,,,(,,,?+/

,, "@$M$$%'O

"        

        

Ophthalmology,000R,/1(,03?0

,+ V  92$  =  <$  &=   et al.

P          

!          

          

Br J Ophthalmol+//3R(1/.?3

,. M  M$  &=  $  4!  

2

Br J Ophthalmol+//3R(,31 ? 3

,3 9N$<&$9%%&$&$

M  M$  K    9#

(

OP&

+/,0R0(,3 

, 4$

      +//3 Curr Opin

Ophthalmol. +//3R15(++0?./3

,1  "O$9$U!%'O$V

V$    M&$  &  O$    2$    $

  9$  @  9$    O  N'

 (     

+/, R.,,+(,1#1.

,  P Y@$ 4U$@MY$ = 9(

P          

!P<+/,.R.(

0#, 

, TX$U=$TY$=$4

X(

2        !    #

&+/+/,,R00. 

,0 &&$4#&$M&$

"  $  <  &P     

    (  V    

PPO

-+/,O,R..(+11# ,

+/ 4  2  2      

  >  -  W

K+/,V,R0,3(,+,#0

+, [%#K\%S%2@$#<OM$V

2$M#4%-$<]%#&2$

@#=^%  V  2  



(!#

Journal of Medical Sciences. 23 Jan, 2023 - Volume 11 | Issue 1. Electronic - ISSN: 2345-0592

14

&(P<

+/+,V,R.,,(/, ,

Journal of Medical Sciences. 23 Jan, 2023 - Volume 11 | Issue 1. Electronic - ISSN: 2345-0592

15