Aim In current metanalysis we included clinical trials which was performed estimations of skin conductance(SC) changes amongst patients who underwent discomfort and painfull procedures.

Bacground According to some scientific literature  [1-4] response to pain stimulus can be related to activity of sympathetic system and measured using evaluation of skin conductance(SC). Surgical inverventions provokes simpatomimethic response[5] to pain. During invasive procedures due to discomfort of patients, changes in skin resistance can be observed[6] while other studies reveals significant skin conductance changes during induction of aneshtesia[5]. Generally skin resistance measurment is defined as an objective tool to evaluate discomfort in invasive procedures[6]. Perioperative[5] stress could be measured by sympathetic nervous system(SNS) and skin conductance monitoring.

Conclusions Combining SC and electromyography(EMG) settings allows researchers to observe and identify live threatening emotional conditions for patients[7]. Clinical trials with galvanic skin response (GSR) and SC measurements uses new settings like frequencies and localizations by placing electrodes directly on fingers in comparison with placing electrodes through clothes[8]. Every response to pain stimulus can differ[4] depending on individual basis. SC output variables are used in several different indices and suggests SC as reliable tool to assess or even differentiate pain stimulus[9,  10].

Keywords: metanalysis, pain, anesthesia.