Mean platelet volume: its relation to permanent atrial fibrillation and peripheral artery disease

Neringa Taparauskaitė1, Edita Mašanauskienė1, Edita Taparauskienė1

1Lithuanian University of Health Sciences, Faculty of Medicine


Mean platelet volume (MPV) is a part of a complete blood count. It shows the average size of thrombocytes and can be associated with  inflammation and thrombosis. Higher MPV values are found in ischaemic stroke, acute myocardial infarction, deep vein thrombosis and pulmonary embolism. The aim of the study was to determine the relation of MPV to permanent atrial fibrillation (AFib) and peripheral artery disease (PAD). A total of 180 patients were enrolled into the study. Participants were divided into two groups: patients with permanent AFib and patients in sinus rhythm. Ankle-brachial index (ABI) was measured, 5-MHz Doppler was used to measure the systolic arterial blood pressure in the lower extremities. MPV was higher in patients with permanent AFib (8.635±1.476 fl in sinus rhythm group, 9.131±1.202 fl in AFib group) (p=0.015). Permanent AFib was more prevalent in patients with ABI<0.9 and MPV>8.55 fl than in patients with ABI>0.9 and MPV<8.55 fl (p=0,001). Higher MPV was associated with higher odds of PAD (OR 1.608, 95% CI 1.243 – 2.081) (p=0.001) the relation remained significant after adjusting for gender and age (adjusted OR 1.612, 95% CI 1.248 – 2.098) (p=0,001). MPV was higher in patients with PAD and the cut-off value to predict PAD was 8.55 fl. At the cut-off value of 8.55 fl, sensitivity of MPV to predict PAD was 76%, specificity – 61%.

Keywords: mean platelet volume, atrial fibrillation, peripheral artery disease.