Overview of the treatment of toxic epidermal necrolysis

Agnė Alseikaitė1

1Lithuanian university of health sciences, faculty of Medicine



Toxic epidermal necrolysis (TEN) are severe mucocutaneous adverse reactions, most commonly triggered by medications, characterized by fever and extensive necrosis and detachment of the epidermis. TEN is the most severe involving greater than 30% of the total body surface area (TBSA). Management of these patients usually benefits from a large multidisciplinary team for both wound and medical management. Treatment of these patients varies between centers and physicians and there is lack of a standardized treatment protocol in the medical literature. Aim: to select and analyse expert-developed and universally accepted guidelines for the treatment of TEN and to determine the most effective methods for the treatment of TEN. Material and the methods: a review of the literature was conducted using the electronic medical database “PubMed” (MEDLINE), selecting publications which contains expert recommendations on the treatment of TEN. Combination of the key terms “toxic epidermal necrolysis”, “TEN”; “treatment” and “guidelines” was used. Conclusion: Due to the rarity of this condition and huge variety in treatment modalities used it is difficult to back them with evidence. By reviewing the literature and undertaking this study, was created treatment recomendations by a multidisciplinary team.

Keys: toxic epidermal necrolysis; treatment; skin disease.